LENS Webinar #10,
Global Health Threats:
Drug development & drug delivery systems
Dr. Andrey Kovalevsky
(Oak Ridge National Laboratory)
‘Targeting the Heart of a Virus: Design of SARS-CoV-2 Main Protease Inhibitors using X-rays, Neutrons and Computation’
Dr. Marianna Yanez Arteta
‘Lipid Nanoparticles for mRNA delivery:
using Neutron Scattering for their successful redesign’
25 March 2021, 3:00pm CET
Chair: Zoë Fisher (ESS)
Join via Zoom: https://ill.zoom.us/j/99877481390
15.00: Andrey Kovalevsky | 15.30: Marianna Yanez | 16-16.30: Discussion
Dr. Andrey Kovalevsky is a structural biologist, biochemist, and drug designer. Dr. Kovalevsky received M.Sc with Honors from Kharkov State University, Kharkov, Ukraine, and a Ph.D. from the University at Buffalo, the State University of New York. He worked at Georgia State University and the Los Alamos National Laboratory before joining the Oak Ridge National Laboratory, where he is currently a Senior R&D Scientist.
Dr. Kovalevsky’s current research focuses on studying the structure-dynamics-function relationships in macromolecular drug targets, including the design of protease inhibitors against SARS-CoV-2 and antidotes against nerve gas and pesticide poisoning, and studies of vitamin B6-dependent enzymes. His approach combines innovative biophysical and computational methodologies, such as X-ray and neutron crystallography at near-physiological conditions, vibrational spectroscopy with neutrons, biomolecular simulations, and structure-based virtual reality (VR)-assisted drug design.
Dr. Marianna Yanez Arteta is an Associate Principal Scientist at the Advanced Drug Delivery division within Pharmaceutical Sciences in AstraZeneca. In her current position she leads the development of new modalities drug products in pre-clinical and early clinical phases, including mRNA, antisense oligonucleotides and peptides. As part of her role, she has guided the development of nanomedicines for complex therapeutics from the understanding of the molecular interactions in the formulation.
Previous to this, Marianna was a postdoc researcher at AstraZeneca, where she investigated the structure of lipid nanoparticles for mRNA delivery using among other techniques neutron scattering. This work lead to a rational redesign of their composition in order to increase their efficacy. Marianna has a PhD in Physical Chemistry from Lund University, with considerable experience in the use of neutron scattering to investigate colloidal systems. She brings her expertise in scattering techniques to the screening of formulations in pre-clinical development.
Recent News & Events
- On the 15th of September 2021, the governments of France, Germany and the United Kingdom signed a protocol that will extend their support of the Institut Laue-Langevin (ILL) for another ten-year period from 2024 to 2033.
- Welcome to the first issue of the LENS Initiative newsletter. Established in 2018, the LENS Initiative is the result of a long and productive partnership between European neutron facilities, working to advance neutron science and technology across the world. With the launch of this newsletter, we look forward to bringing you updates on the latest activities and opportunities from LENS.
- 27 May: LENS Webinar #11 ‘Ultra-high field magnets for neutron scattering: latest developments and possibilities ‘ Mark Bird (NHML Tallahassee)This webinar will address possibilities for higher field magnets for neutron scattering, focusing on the possibilities opened up by the high temperature superconductors but also touching on dc and pulsed resistive magnets.