Neutron research in the fight against viral diseases: Covid-19, AIDS, Influenza and others
As with HIV before it, Europe’s advanced neutron sources will make an essential contribution to the fight against the SARS-CoV-2 virus. Modern analytical tools such as synchrotron X-ray radiation, cryo-electron microscopy and neutron scattering are indispensable for important insights into the morphology and functionality of viruses. Neutron scattering’s particular role here is to provide unique information on the chemistry of enzymatic reactions that often involve proton transfer. Recent studies on HIV-1 protease, an enzyme essential for the life-cycle of the HIV virus, perfectly illustrate the case. To fight Covid-19, a variety of neutron scattering methods will be required to get the full picture of the “invisible enemy” the world has found itself at war with.
Here we offer a selection of both groundbreaking and recent articles and papers demonstrating the impact of research at Europe’s large-scale neutron facilities on humanity’s persistent battle against viruses.
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- LENS Webinar #10 on ‘Drug development and drug delivery systems ‘ with Andrey Kovalevski (ORNL) & Marianna Yanez Arteta (AstraZeneca Mölndal)This webinar will focus on how neutrons can provide crucial information to study the structure-dynamics-function relationships in macromolecular drug targets and to design successful drug delivery systems.
- LENS Webinar #9 on ‘Elucidating amyloid aggregation mechanisms behind neurodegenerative diseases’ with Emma Sparr (Lund University) & Pau Bernado (CBS/CNRS Montpellier)This webinar will focus on how neutron scattering techniques can elucidate the structures and steps involved in the aggregation mechanisms to provide crucial information to understand and combat these diseases and to develop better medications.